Dr. Mitchell S. Albert
Lab Director, MRI Research Chair, Scientist
Dr. Mitchell Albert is a specialist in the field of hyperpolarized (HP) noble gas MRI. He is a co-inventer of this technology, and as a graduate student at Stony Brook University, demonstrated the first ever HP 129Xe MR imaging of the mouse lung. He was awarded a PhD in Physical Chemistry at Stony Brook University in 1993, and he joined the faculty of Harvard Medical School in 1995. While at Harvard, he continued his research on HP gas MRI while simultaneously holding a research appointment at Brigham and Women’s Hospital in Boston.
In 2006, he moved to the University of Massachusetts Medical School, and was appointed Professor and Director of MRI Research. He brought together and led a multidisciplinary team of scientists in advanced MRI research. Dr. Albert joined TBRRI and Lakehead University in Spring 2011. The research focus of his group is on developing HP 3He and 129Xe MRI to image ventilation in the airways and alveoli of the lungs. In addition, his group has been i) developing the use of HP 129Xe MRI to image stroke, ii) planning to image brain injury using xenon bio-sensors in living animals, and iii) imaging breast tumours using specific anti-tumour antibodies. Dr. Albert received the 1999 Presidential Early Career Award for Scientists and Engineers (PECASE) from President Clinton, and the NSF Career Award in 2001 for his work with HP gas MRI.
- B.S. Experimental Psychology, State University of NY, Purchase, NY; 1985
- Ph.D. Physical Chemistry, State University of NY, Stony Brook, NY; 1993
- Postdoctoral Training, Research Fellow in Radiology, University Hospital at Stony Brook, NY; 1993-1994
Appointments and Affiliations:
- Research Chair and Professor, Department of Chemistry, Lakehead University, Thunder Bay, ON; 2011 – Present
- Adjunct Professor, Department of Physics, Lakehead University, Thunder Bay, ON; 2011 – Present
- Adjunct Professor, Biotechnology Program, Lakehead University, Thunder Bay, ON; 2011 – Present
- Instructor of Research in Radiology,University Hospital at Stony Brook, NY; 1994-1995
- Instructor in Radiology, Harvard Medical School, Boston, MA; 1995-1997
- Assistant Professor of Radiology, Harvard Medical School, Boston, MA; 1998-2004
- Associate Professor of Radiology, Harvard Medical School, Boston, MA; 2004-2006
- Professor of Radiology, University of Massachusetts Medical School, Worcester, MA; 2006-2011
- Director of MRI Research, University of Massachusetts Medical School, Worcester, MA; 2006-2011
Dr. Francis T. Hane
BrightFocus Postdoctoral Fellow
Dr. Hane completed his PhD in Biophysics at the University of Waterloo in 2014 under the supervision of Professor Zoya Leonenko. Dr. Hane’s PhD research focused on the single molecule interactions of amyloid-beta the protein implicated in Alzheimer’s disease. Following his PhD, Dr. Hane joined the lab of Professor Mitchell S. Albert. Dr. Hane’s current research focuses on the development of hyperpolarized xenon gas-based MRI contrast agents.
In 2015 Dr. Hane was awarded a post doctoral fellowship from the BrightFocus foundation for the study of novel MRI contrast agent for the early detection of Alzheimer’s disease.
Tao Li received his BSc in Micro-Electronics and MSc in Micro- and Solid-State Electronics from Changchun University of Science and Technology in 2006 and 2009. He received his MSc.Eng in Electrical Engineering from Lakehead University in 2013. Li’s work in this lab focuses on the design and development of MRI RF coils and related RF/electronics systems for small animal and human studies, as well as polarizer development and 129Xe/2He hyperpolarized gas production.
Graduate Student, PhD
Yurii received his Masters of Physics with honor from Taras Schevchenko National University of Kyiv and is currently working on his PhD in Chemistry and Materials Science at Lakehead University. In the lab, Yurii is working on pulse sequence development, developing 129Xe brain imaging and 19F lung MRI improvement. In addition, Yurii is involved in synthesis of fluorinated biosensors and testing of the supramolecular 129Xe biosensor.
Yurii was recently awarded the President’s International Graduate Scholar Award.
Yurii was awarded the Ontario Graduate Scholarship in 2018.
Graduate Student, PhD
Vira received her MSc. with Honors from the Taras Shevchenko National University of Kyiv and has a background in physical chemistry (heterogeneous catalysis). She is now at Lakehead University, studying for her PhD in Chemistry and Materials Science. She is working on the synthesis of fluorinated biosensors, computing potential Xe biosensors, and acquiring and analyzing BOLD fMRI. In addition, she is involved in the testing of supramolecular Xe biosensors and lung studies.
Vira is supported by Ontario Trillium Scholarship.
Past Lab Members
Alanna Wade: HyperCEST MR Studies of Xenon-129 ( 129 Xe) Biosensors and MRI Detection of 129 Xe in the Brain.
Jennifer Plata: Research Assistant.
Raiili Pellizzari: Research Assistant.
Dr. Marcus Couch: Inert and fluorinated gases in the lung. Now a Post Doc at Sick Kids Hospital.
Dr. Iain Ball: Worked on pulse sequence development. Now a Clinical Scientist at Philips.
Gowtham Gajawada: Worked on RF coil development.
Steven Engler: Worked on image analysis tools for volume measurements, heterogeneity, and image registration
Krista Dowhos: Worked on HyperCEST in vitro experiments. Third year medical school student.
Chris Viel: Worked on 3He imaging in mouse lungs, and 19F imaging in inflammatory models
Dr. Alexei Ouriadov: Worked on pulse sequence development and animal lung imaging
Dr. Matt Fox: Worked on 129Xe brain imaging
Dr. Karen Davenport: Worked on metabolic imaging of fluorinated compounds
Peter Smylie: Summer student. Worked on Matlab image processing scripts.
Julia Ruberto: Summer student.